N-Succinyl diaminopimelate aminotransferase (DAP-AT, Fig. 1) is a PLP dependent enzyme from the bacterial lysine pathway. In recent work this enzyme has been isolated and purified from E. coli. We ...

While elevated levels of these enzymes are typically associated with ... can result from deficiencies in pyridoxal 5'-phosphate (PLP, vitamin B6), often seen in conditions such as: Vitamin B6 ...

The proteomes of most bacteria contain 1000-2000 enzymes, and each enzyme has an unknown number of promiscuous activities. Consequently, bacteria can access many thousands of catalytic activities when ...

Inhibition or depletion of sphingomyelinase enzymes reduces the secretion of PLP-containing exosomes. To explore the functional significance of ceramide, the authors generated giant unilamellar ...