Figure 1: EGF induces the PKM2–β-catenin interaction in the nucleus. Figure 2: c-Src phosphorylates β-catenin at Y333 upon EGFR activation. Figure 3: The PKM2–β-catenin interaction is ...

In the Cell Metabolism paper, Verma and the team found that activating the enzyme PKM2 helped boost mitochondrial metabolism in anti-tumor CD8 T cells. Additionally, the team learned that CD8 T ...

SYX-5219 offers first-in-class potential as an oral, targeted, disease-modifying anti-inflammatory therapy, targeting a critical enzyme that regulates cell metabolism called pyruvate kinase M2 (PKM2).

PD-1 blockade with camrelizumab after chemoradiotherapy in nasopharyngeal carcinoma. This is an ASCO Meeting Abstract from the ASCO Breakthrough: A Global Summit for Oncology Innovators. This abstract ...