A report published in PLoS Biology provides evidence that PTEN-induced putative kinase 1 (PINK1) is involved in selective autophagy of dysfunctional mitochondria. Recessive mutations in the PINK1 ...

First, PINK1 senses mitochondrial damage. Then, it attaches to damaged mitochondria. Once attached, it links to a protein ...

Our most recent work is focused on elucidating how a protein kinase (PINK1) controls the activity of a ubiquitin E3 ligase (Parkin) to specify cell fate decisions. Mutations in genes encoding for ...

View Full Profile. Learn about our Editorial Policies. PINK1 triggers a downstream cascade of events that leads to mitophagy—a process by which the cell clears away any mitochondria it doesn’t need. 4 ...

PINK1 and Parkin are two key genes involved in mitophagy, and mutations in these genes are linked to early-onset Parkinson's disease. Until the discovery of two proteins, NAP1 and SINTBAD ...

Two of the proteins, Parkin and PINK1, hang around the mitochondria’s membrane and work as a pair to enable the mitochondria to fuse or degrade. Abnormalities in the genes for Parkin and PINK1 are ...

“GO and KEGG pathway analysis from RNA sequencing showed that PINK1/Parkin-mediated mitophagy pathway was enriched in 786-O-PR. Silencing SLC27A3 significantly reduced the accumulation of LD and ...

Two of the proteins, Parkin and PINK1, hang around the mitochondria's membrane and work as a pair to enable the mitochondria to fuse or degrade. Abnormalities in the genes for Parkin and PINK1 are ...

They may include agents to modulators of kinase activities (e.g., PINK1 and LRRK2), modulators of the activity of the ubiquitin–protein ligase, Parkin, proteostasis agents to block α-synuclein ...