most notably the phosphoinositide 3-kinase (PI3K) enzymes. The lipids generated by these kinases in response to receptor stimulation are asymmetrically distributed in the membranes of chemotaxing ...

As key roles in cancer have been established for PI3K and PTEN — enzymes that regulate the levels of phosphatidylinositol-3,4,5-trisphosphate — compounds targeting this pathway are entering ...

This gene is responsible for the production of phosphoinositide 3-kinase (PI3K), an enzyme involved in cellular growth and function. Somatic (non-inherited) mutations in the PIK3CA gene that occur ...

The frequency of high blood glucose among patients receiving PI3K/Akt inhibitors to treat breast cancer has some oncologists ...

A second drug candidate, BBO-10203, blocks the interaction between RAS and PI3K alpha, a family of enzymes involved in cellular growth and proliferation. While PI3K alpha inhibitors have reached ...

Liver injury is an independent risk factor for multiple organ dysfunction and high mortality in patients with sepsis. However, the pathological mechanisms and therapeutic strategies for ...