Nontraditional risk factors, particularly migraine with aura, play a major role in patients under 50 years old.

Ideally, the definitive results of this trial will mean that percutaneous PFO closure no longer is practiced outside of these trials.

HealthDay News — Traditional risk factors contribute to young-onset cryptogenic ischemic stroke (CIS) without patent foramen ovale (PFO), while nontraditional risk factors seem more important for CIS ...

Traditional risk factors contribute most to young-onset CIS without patent foramen ovale; nontraditional risk factors more important in CIS with PFO. (HealthDay News) — Traditional risk factors ...