Small-molecule approaches that suppress (or reverse) hypertrophy to the extent observed here are uncommon, suggesting that the underlying mechanisms linked to modulation of PDE5A, cGMP and/or PKG ...

PDE inhibitors, in particular the PDE5 (cyclic GMP PDE) inhibitors avanafil, lodenafil, sildenafil, tadalafil, udenafil and vardenafil, are regarded as efficacious, having a fast onset of drug ...

These medications inhibit an enzyme called phosphodiesterase type 5 (PDE5), which breaks down a chemical called cyclic ...

The most abundant PDE in the human corpus cavernosum is the cGMP-specific PDE5; therefore, the inhibition of PDE5 enhances erectile function by increasing the amount of cGMP. Because sexual ...