The cyclic nucleotide phosphodiesterase 4 (PDE4) regulates the hydrolysis of the second messenger cyclic AMP. cAMP is a major intracellular signalling mediator that directly affects the activity ...

The results, published in JCI Insight on April 22, 2025, suggest that the drug apremilast-a phosphodiesterase-4 (PDE4) inhibitor, or a compound that blocks an enzyme involved in inflammation-could ...

Announcing a new publication for Acta Materia Medica journal. Phosphodiesterase-4 (PDE4), a member of the phosphodiesterase superfamily, has highly important roles in cyclic nucleotide signaling ...

Meanwhile, Staquis represents a first-in-class steroid-free topical PDE4 inhibitor for the treatment of mild-to-moderate atopic dermatitis in patients three months of age and older ³,⁴.