The cyclic nucleotide phosphodiesterase 4 (PDE4) regulates the hydrolysis of the second messenger cyclic AMP. cAMP is a major intracellular signalling mediator that directly affects the activity ...

Katalytic Therapeutics Inc. has divulged proteolysis targeting chimera (PROTAC) compounds comprising an E3 ubiquitin ligase binding moiety covalently linked to a phosphodiesterase PDE4-targeting ...

"IN-115314" is a drug that blocks Janus kinases (JAK), proteins related to immune ... calcineurin inhibitors, and PDE4 enzyme inhibitors that cause inflammatory responses, which are either in ...