The cyclic nucleotide phosphodiesterase 4 (PDE4) regulates the hydrolysis of the second messenger cyclic AMP. cAMP is a major intracellular signalling mediator that directly affects the activity ...

The results, published in JCI Insight on April 22, 2025, suggest that the drug apremilast-a phosphodiesterase-4 (PDE4) inhibitor, or a compound that blocks an enzyme involved in inflammation-could ...

LW, a derivative of the natural product Moracin M, was found to have favorable PDE4 inhibitory activity (PDE4 IC 50 = 54 nM). Examination of LW in psoriasis treatment demonstrated good anti ...