The cyclic nucleotide phosphodiesterase 4 (PDE4) regulates the hydrolysis of the second messenger cyclic AMP. cAMP is a major intracellular signalling mediator that directly affects the activity ...

Blocking PDE4 activity with PDE4 inhibitors increases intracellular cAMP levels and effectively relieves the skin inflammatory phenotype of psoriasis. However, traditional PDE4 inhibitors may ...

The results, published in JCI Insight on April 22, 2025, suggest that the drug apremilast-a phosphodiesterase-4 (PDE4) inhibitor, or a compound that blocks an enzyme involved in inflammation-could ...