2 PARP1 is one of the first responders to damaged DNA, and its importance is reflected in its abundance: this enzyme is one of the most common nuclear proteins.3 When PARP1 binds damaged DNA, it adds ...

Figure 1: Domain architecture of the classic poly-ADP-ribose-polymerase PARP1 and the newly characterized mono-ADP-ribosyltransferase PARP10. Figure 2: Classification of the poly-ADP-ribose ...

Cells have another protein called PARP1 — or poly (ADP-ribose) polymerase 1) — that flags damage to the DNA and errors in DNA replication, recruiting repair molecules before searching the ...

So, as BRCA-deficient cells had previously been shown to be highly sensitive to the effects of inhibiting PARP1, Rottenberg and colleagues investigated the effects of the PARP1 inhibitor AZD2281 ...