The first wave of PARP inhibitors has improved outcomes in ... IDX-1197 in patients with advanced solid tumors in 2017 (Fig. 1). The study reported clinical responses and good tolerability ...

When mutations hinder BRCA2 function, cancer cells are known to rely on the poly ADP-ribose polymerase 1 (PARP1) pathway for backup DNA repair, and to continue abnormal growth. PARP inhibitors were ...