The chip was integrated with PDAC spheroids, structures made of PANC-1 cells – a human pancreatic cancer cell line – and pancreatic stellate cells. This gives the model three-dimensional cell ...

In particular, the treatment resulted in: -- A ~70 percent reduction in tumor cell numbers in the AsPC-1 model (KRAS G12D mutation). -- A dose-dependent reduction in tumor size in Panc-1 models ...

In Panc-1 (harbouring KRAS G12D mutation): Bioluminescence or tumor cell numbers decreased dramatically in a dose-dependent manner, with the highest-dose group showing the most significant effect.