To explore this, we studied the interaction between the virus and the main mutation caused by UV, p53 mutation, using experimental models and human tissue samples. We found that UV-induced p53 ...

p53 and RB are at the heart of the two main tumour-suppressor pathways that control cellular responses to potentially oncogenic stimuli. Each pathway consists of several upstream regulators and ...

The ATM gene (mutated in the disease ataxia telangiectasia) activates the p53 tumor suppressor protein in response to DNA damage, explaining the higher incidence of cancer in AT patients.