Australian researchers have discovered that a single mutation in the DNA sequence for a methylation enzyme dysregulates key ...

Australian researchers have discovered that a single mutation in the DNA sequence for a methylation enzyme dysregulates key ...

When analyzing the p53 sequence, she noticed that it looked similar to many other known transcription factors. “At the time, my first hypothesis was it was a transcriptional repressor,” Lozano ...

Sustained reactivation of mutant p53 drives durable anti-tumor activity across models, including KRAS co-mutant tumors FMC-220 selectively stabilizes p53 Y220C at lower doses, overcoming key ...

PMV Pharmaceuticals, Inc.’s PMVP share price has surged by 7.83%, which has investors questioning if this is right time to ...

In lab experiments, the researchers found that navtemadlin was one of the best drugs at killing glioblastoma cells with intact, non-mutant p53. The work appears in Science Translational Medicine.

In the study, patients with advanced solid tumors must be HLA-A*02:01 positive and harbor a p53 R175H mutation.

CAMBRIDGE, MA and ROCKVILLE, MD, USA I April 28, 2025 I Clasp Therapeutics, a biotechnology company bringing unparalleled precision to immuno-oncology with ...