So far, these have mainly probed two of the best-studied p53 outputs, growth arrest and apoptosis. Figure 2: A model of the p53–miR-34 network in regulating cell proliferation and cell death.

CAMBRIDGE, MA and ROCKVILLE, MD, USA I April 28, 2025 I Clasp Therapeutics, a biotechnology company bringing unparalleled precision to immuno-oncology with ...

Conversely, the transcriptional targets of p53—a cell cycle regulator often mutated in cancers—such as CDKN1A and MDM2—were upregulated in these cells. In addition, markers of cellular ...