This results demonstrated that p53 was functional active. However, the other hand, the 57-kD MDM2 isoform but not the 76-kD and 90-kD MDM2 isoforms was increased in the plasma from lung cancer ...

p53 and RB are at the heart of the two main tumour-suppressor pathways that control cellular responses to potentially oncogenic stimuli. Each pathway consists of several upstream regulators and ...

The ATM gene (mutated in the disease ataxia telangiectasia) activates the p53 tumor suppressor protein in response to DNA damage, explaining the higher incidence of cancer in AT patients.

The p53 and phospho-p53 proteins were significantly ... respectively [± SD]), in comparison with the other groups. The 57-kD MDM2 isoform plasma concentration was very high in LCW and LCT samples ...