A team of CiRA researchers has uncovered the crucial role of EIF3D—a protein translational regulator—in primed pluripotency.

Around this time, cancer researchers across different disciplines concluded that the gene encoding p53 was an oncogene. Once they started searching, scientists found p53 in almost every cancer type.

Although there are tumor suppressor genes in normal cells to prevent cancer, gene mutations can cause a normal cell to become ...

Loss of normal p53 function has been associated with resistance to both chemotherapy and radiotherapy. Introduction of wild-type (wt) p53 by means of adenoviral vectors has been shown to inhibit ...

Stressed mitochondria can cause senescent cells to form CCF and dampen the expression of the gene carrying the blueprint for p53. “Altogether, we’ve identified a cellular circuit capable of ...

Why did you focus on p53 when developing prime editing sensor libraries? We used p53 as a prototype for several reasons. The gene that encodes p53 is the most commonly mutated cancer gene, and there ...

Stressed mitochondria can cause senescent cells to form CCF and dampen the expression of the gene carrying the blueprint for p53. "Altogether, we've identified a cellular circuit capable of ...

Stressed mitochondria can cause senescent cells to form CCF and dampen the expression of the gene carrying the blueprint for p53. "Altogether, we've identified a cellular circuit capable of ...

The aim of the present work was to establish an association between wood smoke exposure and lung cancer pathogenesis, and to analyze the effects of wood smoke on p53 and murine double minute 2 ...