24 Guillermina Lozano entered the p53 field as a postdoctoral fellow in Levine’s lab in 1985 and continued researching its functions later as a geneticist at University of Texas MD Anderson Cancer ...

Genes Dev 2004). Because p53 functions as a tetramer (i.e. it binds DNA as a tetramer), co-expression of Δ40p53 and WTp53 will form Δ40p53:WTp53 tetramers with mixed stoichiometry. This presents a ...

p53 normally functions to gauge DNA damage, halt cell-cycle, and activate the apoptotic pathway. The E7 viral oncoprotein has been shown to bind to retinoblastoma protein (Rb), releasing E2F from ...

Sustained reactivation of mutant p53 drives durable anti-tumor activity across models, including KRAS co-mutant tumorsFMC-220 selectively stabilizes p53 Y220C at lower doses, overcoming key ...

P47S, a rare polymorphism in the N-terminal transactivation domain of p53, results from a C>T base substitution at position 1 of codon 47. It has only been reported in populations of African ...

However, p53 can mutate and is then no longer able to entirely fulfil its actual function: Cell growth is no longer delayed, there is no time for repairs and cell death is not initiated.

(August 2021) Publication in PLoS Biology (Levandowski et al.) that defines how a naturally occurring p53 isoform, called ∆40p53, alters WTp53 function. Using a combination of genome-editing, ...