By understanding how cancer cells bypass safeguards like p53, scientists can find better ways to stop them, leading to more effective treatments for patients. Each cell contains DNA that instructs ...

A team of CiRA researchers has uncovered the crucial role of EIF3D—a protein translational regulator—in primed pluripotency.

The research team turned human cells senescent by exposing them to radiation and then used those cells to demonstrate that DNA fixer tumor protein p53 suppressed SASP and one of its triggering ...

Disappearance of SUMO-modified Mdm2, which is observed upon radiation, may thus be a prerequisite for DNA-damage-induced accumulation of p53. Figure 2: Destructive pathways: SUMOylation of Mdm2 ...

Deborah Kelly, Pennsylvania State University They didn’t know what genes p53 regulated, so she and her team replaced tp53’s DNA binding domain with the one from GAL4, a galactose-responsive ...

The ATM gene (mutated in the disease ataxia telangiectasia) activates the p53 tumor suppressor protein in response to DNA damage, explaining the higher incidence of cancer in AT patients.

More information: Karl N. Miller et al, p53 enhances DNA repair and suppresses cytoplasmic chromatin fragments and inflammation in senescent cells, Nature Communications (2025). DOI: 10.1038 ...

The research team turned human cells senescent by exposing them to radiation and then used those cells to demonstrate that DNA fixer tumor protein p53 suppressed SASP and one of its triggering ...

The aim of the present work was to establish an association between wood smoke exposure and lung cancer pathogenesis, and to analyze the effects of wood smoke on p53 and murine double minute 2 ...