Among the p53 target genes are WAF1, an inhibitor of cyclin-dependent protein kinases (CDKs) that, among other activities, causes cell-cycle arrest, and BAX, which promotes apoptotic cell death.

Conversely, the transcriptional targets of p53—a cell cycle regulator often mutated in cancers—such as CDKN1A and MDM2—were upregulated in these cells. In addition, markers of cellular ...

These follicles repeatedly cycle through three distinct phases ... which triggered the P53 protein essential for regulating cell death. However, deletion of a P53 gene restored hair growth ...

The aim of the present work was to establish an association between wood smoke exposure and lung cancer pathogenesis, and to analyze the effects of wood smoke on p53 and murine double minute 2 ...