One such mechanism involves a protein called p53. Often dubbed the "guardian of the genome," this protein plays a pivotal ...

Among those genes, TP53 (encoding the p53 protein) has been identified as the most frequently mutated gene that causes cancer ...

Advancing these concepts are major goals of our current research. 1. Martins CP, Brown-Swigart L, Evan GI. Modeling the therapeutic efficacy of p53 restoration in tumors. Cell. 2006;127(7):1323-34. 2.