Recent work has discovered the role of the cyclin-dependent kinase (CDK)-binding protein Cks1 in degrading the CDK inhibitor p27 Kip1. This process is essential for DNA replication and is ...

Because of flexibility, the disruption of the p27 Kip1 –cyclin A–Cdk2 complex can proceed in a step-wise, segmental fashion, which likely provides a kinetic advantage for the overall process.

"There have been reports that p27 Kip1 levels drop following injury, so that might offer a brief window of opportunity for using a drug-like compound to inhibit the Hippo pathway and encourage ...