of mutations in CDK4/6 that confer resistance to CDK inhibitors, and of reduced expression of p27 KIP are associated with various lymphomas, adenomas, carcinomas and gliomas. These properties of ...

Recent work has discovered the role of the cyclin-dependent kinase (CDK)-binding protein Cks1 in degrading the CDK inhibitor p27 Kip1. This process is essential for DNA replication and is ...