This association was maintained in an analysis stratified according to the histologic features of the tumor (P=0.03). The 13 patients whose tumors showed both overexpression of p53 and mutations ...

The p53 tumour suppressor has an important role in cancer cells. Here we show that p53 regulates expression of major histocompatibility complex I on the cell surface. We show that the tumour cell ...

Scientists have recently shed some light on exactly why elephants, one of the biggest animals on the planet, paradoxically ...

with microsatellite stability had a high p53 labeling index (P<0.001). Among the tumor specimens that had high levels of microsatellite instability and that were evaluated with dinucleotide and ...

p53 is one of the most important proteins in cancer biology. Often referred to as a "guardian of the genome," p53 becomes activated in response to various cellular stressors like DNA damage.

"Our study unveils a molecular mechanism for p53 downregulation and activation of p-mTOR1 and its substrates in GPR141 overexpressed cells, accelerating breast tumorigenesis." In their current ...

C-erbB-2 immunoreactivity was present in 18 cases (20%) and was associated with undifferentiated histiotype (P < .05), but not with PFS or overall survival. p53 immunoreactivity was present in the ...

It might also eventually cause tumors. Unfortunately, p53 is also something of a natural defense against the kinds of changes to the genome made by CRISPR-Cas9. When researchers use CRISPR-Cas9 to ...

Lamassu Biotech Inc. has announced that its IND for SA53-OS has been cleared by the FDA in the U.S. The planned phase I/IIa trials will investigate the genetically targeted therapy that blocks the ...