Of the available NSAIDs, oxicam derivatives appeared to have the greatest association with SJS and TEN. The relative risks reported with other NSAIDs are much lower. The risk with cyclooxygenase-2 ...

Phenylbutazone derivatives, which are no longer marketed in the United States, accounted for 16 cases of SJS or TEN (including 2 deaths), while oxicam derivatives (i.e., piroxicam, isoxicam ...