By using a compound derived from a Himalayan fungus and used for centuries in Chinese medicine as a jumping off point, ...

"Nucleoside analogs are among the most important molecules to the advancement of modern medicine," says Michael Meanwell, assistant professor in the Department of Chemistry and corresponding ...

Throughout history, many viral diseases have proven difficult to treat. However, recent research into synthetic drugs has ...

Deoxynucleoside analogues such as 5-aza-2-deoxycytidine (depicted by Z) are converted into the triphosphate inside S-phase cells and are incorporated in place of cytosine into DNA. Ribonucleosides ...

(A) Nucleoside triphosphates serve as a substrate for DNA polymerase, according to the mechanism shown on the top strand. Each nucleoside triphosphate is made up of three phosphates (represented ...

The HIV treatment landscape has further evolved with the introduction of LAI therapies, offering alternatives to daily oral ...

Inosine is a nucleoside that occurs naturally in transfer RNAs (tRNAs) and is essential for proper RNA translation. It is commonly found at the wobble position of anticodons, allowing for greater ...

Early clinical and preclinical findings presented at the 35th European Society of Clinical Microbiology and Infectious ...