Under normal stress conditions, the body activates a protective protein called Nrf2, which helps cells resist ...

Researchers have developed a new therapy that can be injected intravenously right after a heart attack to promote healing and prevent heart failure. The therapy both prompts the immune system to ...

Image Caption: Mechanisms of resistance to chemoradiotherapy in osteosarcoma. In chemoradiotherapy resistant OS cells, altered expression of the drug transporter proteins, RFC and ABC family ...

Though NRF2 performs some very important functions, it can also be deadly if it runs amok. In many vertebrates, overactive NRF2 triggers big problems like tumor growth. “It’s very much a ...

Chemoresistance is the most significant challenge affecting the clinical efficacy of the treatment of patients with gastric cancer (GC). Here we reported that transmembrane protein 160 (TMEM160) ...

Researchers have developed a new therapy that can be injected intravenously right after a heart attack to promote healing and ...

Central to this breakthrough is Nuclear factor E2-related factor 2 (Nrf2), a transcription factor now recognized as a pivotal player in chemoradiotherapy resistance. Traditionally acknowledged for ...

A deeper understanding of osteosarcoma, the most common primary malignant bone tumor affecting children and adolescents, is ...