Melanomas with mutations in the NRAS gene, known as NRASMUT melanomas, account for nearly 30% of all cases. These tumors are ...

Dr. Mohamed Fareh and colleagues have shown it is possible to silence the KRAS G12, NRAS G12D, and BRAF V600E gene mutations known to drive aggressive pancreatic, colorectal and lung cancers.

We assessed six cell lines known to harbor Nras gene mutations using our multicolor multiplex assay. Two of the cell lines, MOLT-4 and PA-1, contain mutations in codon 12, while the remaining four ...