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Canonical signaling involves the cleavage of NOTCH receptors and the subsequent activation of target genes through the NICD-RBPJ complex. Noncanonical signaling involves interactions with other ...
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Understanding the roles of NOTCH signaling in cancer resistanceCanonical signaling involves the cleavage of NOTCH receptors and the subsequent activation of target genes through the NICD-RBPJ complex. Noncanonical signaling involves interactions with other ...
With this unique approach, Cellestia has been able to close an important gap in the quest to break multi-drug resistance in cancer, as CB-103 can effectively take out the Notch/CSL–NICD–MAML ...
γ-Secretase performs the subsequent cleavage at S3 releasing Notch intracellular domain (NICD) from the membrane and allowing for signal transduction through binding with the CBL-1, Su(H), Lag-1 ...
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