The researchers outfitted CD4+ T cells with synthetic Notch (synNotch) receptors—highly programmable ... which is implicated in autoimmune diseases and B cell cancers, then engineered cells to release ...

"Although B cell lineage plasticity has been observed ... "Because we showed that Notch, a receptor in a highly conserved cell signaling pathway, was involved in the process, this could mean ...

Researchers have uncovered a critical, previously underappreciated role for B cells in vaccine protection. Best known for producing antibodies, B cells also guide other immune cells, specifically CD8 ...