Loss of normal p53 function has been associated with resistance to both chemotherapy and radiotherapy. Introduction of wild-type (wt) p53 by means of adenoviral vectors has been shown to inhibit ...

Research over the last three years has shown that p53 is mutated in diverse forms of human tumors. The papers noted above provide some basic information about the nature and effects of these mutations ...

After DNA damage by IR, normal cells accumulate p53 and show an increase in p53 transcriptional activity, whereas cells from AT patients that have defective ATM show only a very small increase in ...

Once everybody got on the same page, the community settled on a common name: p53. “The field looked at this and didn’t know what to make of it,” Levine said. “Because it wasn’t isolated like an ...

In the study, patients with advanced solid tumors must be HLA-A*02:01 positive and harbor a p53 R175H mutation.