This reaction is repeated to form ubiquitin chains. This study found that the ubiquitination that inactivates Nrf1 was performed by two E3s (SCF FBS2-ARIH1) and one E2 (UBE2L3), which bind to the ...

The search turned up a few molecules that might be involved in cholesterol regulation, but the team zeroed in on the protein Nrf1, the levels of which increase when cellular cholesterol rises.