With collaborators at the Cambridge (UK) Stem Cell Institute, led by Konstantinos Tzelepis, PhD, and Maria Eleftheriou, PhD, they show that one RNA-binding protein on the cell surface, NPM1 ...

Led by Ryan Flynn, MD, PhD, assistant professor of stem cell and regenerative biology at Harvard Medical School (HMS), the study identified one RNA-binding protein on the cell surface, NPM1 ...

However, loss of p53 tumour-suppressor activity can also occur through amplification of MDM2. As MDM2 is a negative regulator of p53, this promotes p53 degradation and inhibits p53 tumour ...