RIPK1 and NLRP3, to become overactive. This overactivity leads to excessive cell death and people with a mutation in the TBK1 gene often experience inflammation in multiple organs. Led by Jelena ...

They report that MCC950 dampened the induction of neurotoxic astrocytes, alleviating neuroinflammation and depression-like behaviors, just as their NLRP3 gene knockout experiments had. The authors’ ...

Then, in 2001, researchers in California discovered the genetic explanation for his disease: a mutation in a gene called CIAS1 (since renamed NALP3 and then NLRP3), which was later found to cause the ...

Appointment of seven recognized experts is validating for Ventyx’s NLRP3 Program AD/PD™ 2025 provides helpful insights on potential next steps in Parkinson’s disease SAN DIEGO, April 01 ...