BioAge Labs, Inc. (NASDAQ: BIOA) ("BioAge", "the Company"), a clinical-stage biotechnology company developing therapeutic product candidates for metabolic diseases by targeting the biology of human ...

A research team has unveiled the cause and molecular mechanism of chronic brain inflammation that results in repetitive ...

By targeting ASC, IC 100 inhibits activation of multiple inflammasome pathways activated in obesity (NLRP3, AIM2), heart failure (AIM2, NLRP3, NLRC4), and insulin resistance (AIM2, NLRP1 ...

They are working towards stopping the problem at its root, offering hope for healthier and longer lives. If successful, these ...

Image Credit: Kateryna Kon/Shutterstock.com The NLRP3 inflammasome constitutes an intracellular complex of multiple proteins that promote caspase1 autocatalysis and the consequent maturation and ...

VENT-02 is a novel, oral, brain-penetrant inhibitor of NLRP3, a key driver of inflammation and component of the innate immune system that plays a critical role in a wide range of inflammatory ...

“These remarkable findings … suggest that in obese mice consuming a high-fat diet, brain-penetrant NLRP3 inhibition and the resulting anti-inflammatory effect confers not only reversal of ...

Studies have shown that brain inflammation causes compulsive repetitive behavior. This is the result of a research team led by Um Ji-won, a professor of brain science at the Daegu Gyeongbuk Institute ...

Alzheimer’s disease stands as the most widespread form of dementia globally, increasingly burdening families, healthcare ...

BioAge Labs, Inc. announced progress in their development pipeline, highlighting the advancement of their oral NLRP3 inhibitor BGE-102, with initial clinical data expected in the second half of 2025.

NodThera’s NLRP3 inhibitor has already proved its worth against Novo Nordisk’s blockbuster obesity drug in preclinical trials. Now, an early readout from a study in humans with obesity has ...

Neushen Therapeutics Inc. has described NLRP3 inflammasome inhibitors reported to be useful for the treatment of autoimmune disease, cardiovascular disorders, neurodegeneration and chronic obstructive ...