The cytosolic ubiquitin ligase Nedd4-1 is known to promote autophagy. Here, the authors characterize a primate-specific splice isoform, Nedd4-1(NE), that is localized to late endosomes in the ...

[19,20] These regions are important to regulation of ENaC activity as they facilitate binding of Nedd4, a regulatory repressor that promotes channel degradation. The inability of beta and gamma ...