About one quarter of older men who were homozygous for the HFE C282Y mutation had clinically evident disease. Most clinical cases of hereditary hemochromatosis occur in people who are homozygous ...

The variable expressivity of HFE-HH is related to sex and dietary factors; however, other mutations, and environmental factors such as steatosis and viral hepatitis may also contribute to clinical ...

Loss-of-function mutations of the HFE gene lead to an autosomal recessive iron-overload disorder referred to as hereditary hemochromatosis (HH). Excessive hepatic iron accumulation is observed in ...