“We found that there was an interesting change in mammoths and also an interesting change in the mouse version of these genes that led to a predictable phenotype. This was the sweet spot, and to test ...

we decided to look for similar pathways and edits in similar genes to ensure that the edits we were going to make in our our woolly mice would be compatible with life while driving the core genotype ...

Because newly weaned Cftr –/– mice are weak, solid chow was soaked with laxative during the first week after weaning. Subsequently, part of these animals were followed-up for a longer period ...

The Mouse Metabolism and Phenotyping Core is a comprehensive fee-for-service rodent phenotyping core providing investigators with a wide variety of state of the art equipment and techniques. We work ...

The Knockout Mouse Phenotyping Program (KOMP2) sites at Baylor College of Medicine, Jackson Laboratory, and University of California, Davis, are collaborating with the International Mouse Phenotyping ...

The two most popular explanations for incomplete penetrance, genetic background and variable expression levels, did not explain the lack of phenotype in 30% of the mice (Pereira et al., ...

Rationale.The central nervous system (CNS) is the most complex structure of the animal organism both in terms of its development and function. CNS phenotyping requires special skills and equipment, ...

A radical new theory rewrites the story of how life on Earth began “The work done on these mice does not mean that there is a ready solution to bring back a mammoth phenotype,” says team ...

The Ca2+ stored in the cellular endoplasmic reticulum (ER) plays a crucial role in protein folding and lipid transfer, and its impairment leads to cellular ER stress. When chronic cellular ER stress ...

To examine the impact of a low-carb diet on colorectal cancer, researchers conducted experiments on mice, comparing the effects of normal, low-carb, and Western-style diets while analyzing various ...