Their findings revealed that IFN-γ signaling activation and ERK/MAPK signaling inactivation contribute to age-related changes in the intestinal epithelium. Using mouse models, the researchers ...

Aberrant activation of the Ras/Raf/MAPK/ERK kinase/extracellular signal-regulated kinase cascade and the VEGF pathway are commonly observed in breast cancer cells leading to malignant cell ...

and extracellular signal-regulated kinase (ERK)/mitogen-activated protein kinase (MAPK) signaling is essential for preserving ...

Its pipeline includes Tipifarnib, which is a Farnesyl transferase inhibitor for HRAS Mutant Solid Tumors, Chronic Myelomonocytic Leukemia, KO-947, which is an ERK inhibitor for MAPK Pathway Tumors ...

2020 Oct;61(10):1428-1434. doi: 10.2967/jnumed.120.241984. Epub 2020 Aug 28. PMID: 32859706. Synthesis of the PET Tracer 124I-Trametinib for MAPK/ERK Kinase Distribution and Resistance ...