Ferran Adria, who shut El Bulli in Roses, Spain, last year, capped MAD2 in what came across as a sweeping passing of the torch (reminding up-and-comers to respect their forebears) that culminated ...

The Mad2 deregulation was assessed using chromatin immunoprecipitation-qPCR assay in the core promoter region, establishing its association with the pRb-E2F1 circuit for the first time.

WT1 interacts with MAD2 during mitosis A yeast two-hybrid screen performed with a discrete region of mouse WT1 protein (residues 245–297; that contains the 17AA) using a HeLa complementary DNA ...

We show that MAD2 down-regulation induces premature senescence in the MCF7 breast epithelial cancer cell line. These MAD2-depleted (MAD2↓) cells are also significantly replicative incompetent ...

The Mad2 deregulation was assessed using chromatin immunoprecipitation-qPCR assay in the core promoter region, establishing its association with the pRb-E2F1 circuit for the first time.

MAD2gamma, a novel MAD2 isoform, expression in multiple cancer cell lines, mitotic arrest effects, and association with cisplatin-resistance in testicular germ cell tumors. Authors: Alejandro ...

In addition, we are examining the role of the mitotic checkpoint gene Mad2 in maintaining genome stability by ensuring proper chromosome segregation during mitosis. Molecular Mechanisms of ...