partly by regulating Wnt/β-catenin signaling and the transcription factor Myc. Conversely, iMEK or IFN-γ treatment independently triggered age-related changes in enteroendocrine cells and ...

When MYC ecDNA levels soared ... “We knew the tumor’s surroundings could drive changes, but not that WNT signaling could so directly rewrite DNA,” Bailey commented.

NOTCH induces MYC, connecting two signaling programs that enhance oncogenicity. Here we show that this relationship is bidirectional and that MYC, via a miRNA intermediary, modulates NOTCH.

The work demonstrates that initial MYC activation attracts immune cells ... As the tumor progresses, it stops signaling to the immune system and goes undetected. The discovery may help explain ...

Our current research specifically focuses on therapeutic strategies aiming to exploit MYC oncogene-induced vulnerabilities and therapeutically intervenable oncogenic functions of transmembrane serine ...