We developed a novel strategy for delivering oncogenic c-Myc inhibitors for targeting melanoma cells. c-Myc prodrugs (PDs) were developed based on Sn-2 phospholipid PDs by coupling 10058-F4 ...

After discovering that blocking MYC activity was feasible, they identified a novel small molecule, MYC inhibitor 361 (MYCi361), which showed initial promise in suppressing in vivo tumor growth in mice ...

Expression of the cell cycle inhibitor p15 INK4b is suppressed by the Myc oncoprotein and induced by transforming growth factor-β (TGF-β). The transcription factor Miz-1 activates the Ink4b ...