A new study published in Life Science Alliance reveals a key genetic connection between cancer susceptibility and tissue ...

Does MYC binding to chromatin serve transcription-independent functions, including the regulation of chromosomal integrity, gene expression, chromatin structure, cellular replication and genomic ...

They found i-motifs in the MYC gene family, whose activity is known to be dysregulated in around 70% of human cancers. "This presents an exciting opportunity to target disease-linked genes through ...

In their paper the researchers’ stated, “Collectively, our work establishes MYC ecDNAs as a key driver ... enabling tumor cells to swiftly ramp up gene expression, change their shape, and ...