All the ARF-null Eμ-myc cell lines consistently showed an increasing proportion of cells in the sub-G1 fraction from 1 to 5 h post-treatment with only a slight increase in cells positive for ...

MYC family genes are essential for the human organism. According to current knowledge, they regulate the expression of most cellular genes. Misregulation of MYC proteins significantly contributes ...

A new review in Genes and Diseases explores the central role of MYC, a master regulatory protein, in the development and progression of cancer, spotlighting its potential as a multidimensional ...

Figure 4: Distinct conformations of the Jas helix in the COI1–JAZ co-receptor complex versus the JAZ–MYC complex. Figure 5: Jas motif peptide competitively inhibits the MYC3–MED25 interaction.

Methylated DNA markers for monitoring palliative chemotherapy response in advanced colorectal cancer. This is an ASCO Meeting Abstract from the 2021 ASCO Annual Meeting I. This abstract does not ...

(A) Control: partial lymph node involvement by Burkitt's lymphoma (left) and follicular hyperplasia (right); there is bright nuclear staining of MYC protein in Burkitt's lymphoma cells, compared with ...

She concluded that "OMO-103 is the first MYC inhibitor to successfully complete a phase I clinical trial and to be ready to proceed to a phase II trial. We have determined the recommended dose for ...

Targeting Myc has not been successful and is still an unmet clinical need for cancer patients. Myc-targeting degraders GT-19715 and GT-19630 show promise for treating AML and lymphoma | BioWorld ...