Medically reviewed by Melissa Nieves, LND Methylsulfonylmethane (MSM) is a naturally occurring chemical in the body. MSM also ...

However, in some people, MSM might cause nausea, diarrhea, bloating, and stomach discomfort. When applied to the skin, MSM is possibly safe when used in combination with other ingredients, such as ...

that MSM could exacerbate liver damage in people with pre-existing liver disease, but no cases of this have been reported. Still, Ms Ramirez has become jaundiced, with yellowing skin and eyes.