In preliminary experiments, 12-week-old MRL/lpr mice were treated with anti-IL-23 antibody for 4 weeks. Compared with IgG-treated controls, anti-IL-23 antibody-treated mice had decreased ...
Finally, the researchers used the MRL-Fas lpr/lpr model of lupus, in which mice produce several autoantibodies, to show that class R INH-ODNs were also active in vivo. Prediseased mice treated ...
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