Matrix metalloproteinases (MMPs) are implicated in tumor growth, angiogenesis, and metastasis, and thus are promising targets for cancer therapies. Koivunen et al. (pp. 749 and 768) describe the ...

Although the active site is similar to many other MMPs, Trygvasson's structure reveals several other targets for designing more specific MMP-2 inhibitors: "One could design drugs that inhibit ...

Among them, MMP-9 plays a particularly significant role in GBM progression and resistance to current treatments. To address this challenge, the researchers investigated tissue inhibitors of ...

Alterations to the balance between matrix metalloproteinases (MMPs) and the tissue inhibitors of metalloproteinases (TIMPs ... patellar tendons from 3-year-old rabbits would have increased MMP ...