Non-hydroxamate-based MMPIs. Most hydroxamate inhibitors lacked specificity and inhibited non-MMP zinc-based enzymes (Box 1). Thus, new compounds were discovered that made use of alternative zinc ...

Methods Total mRNA isolated from ∼100mg tissue samples of normal (n=9) and pathologic (n=12) tendon was assayed by relative quantitative RT-PCR for MMP (-1, -2, -3, -9, and -13), ADAMTS (-1, -4, -5), ...