interferon affecting the tissue inhibitor of matrix metalloproteinase (TIMP)/MMP balance) and monoclonal antibodies that inhibit MMPs and peptide MMPIs, are worthwhile to develop and to combine.

Matrix metalloproteinases (MMPs), a family of zinc-dependent endopeptidases, are capable of degrading almost all protein components of the extracellular matrix (ECM). MMPs have garnered attention as ...